Celiac Disease Vaccine Now Under Trial Could Allow People to Eat Gluten Again

Celiac disease sufferers may soon be able to safely eat gluten, thanks to a new vaccine currently undergoing testing worldwide.

The vaccine, called Nexvax2, targets the immune system to stop the inflammation that typically occurs when people with celiac disease consume gluten. It was first tested in 2011, for the initial trial phase, and was found to be safe.

The company that produces Nexvax2, the Massachusetts-based ImmusanT, received $ 40 million in funding in 2017, allowing them to continue researching the vaccine. The second round of testing will start in Melbourne, before going out to other cities in Australia. ImmusanT hopes to enroll 150 patients from the United States, Australia and New Zealand in the trial.

“The vaccine is designed to target the 90 percent of celiac disease patients with the HLA-DQ2 genetic form of disease,” Dr. Jason Tye-Din, the head of celiac research and gastroenterologist at the Royal Melbourne Hospital, where the trial will start, told the Sydney Morning Herald. “A successful therapy that can restore normal gluten tolerance would revolutionize celiac disease management.”

RELATED VIDEO: Party City Apologizes and Pulls Ad After Offending People with Gluten Allergies

Currently, there is no treatment for celiac disease — the only option is to cut out gluten entirely. While going gluten-free became trendy among health-conscious people in the last decade, for celiac disease sufferers the protein poses a severe risk to their small intestine, and causes diarrhea, abdominal pain and vomiting.

Nexvax2 won’t immediately enable people with celiac to eat gluten again — rather, the vaccine will slowly build up an immunity to the proteins in gluten and end the negative side effects.

“Through this study we anticipate making new insights that will further our ability to demonstrate specific suppression of the immune response to gluten epitopes and associated effects of celiac disease,”Dr. Ken Truitt, ImmusanT chief medical officer, told BeyondCeliac.org.


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Kim Zolciak-Biermann Says She’ll Never Allow Her Estranged Mother Back Into Her Life

Kim Zolciak-Biermann hasn’t spoken to her mother Karen Zolciak in six years — and by the look of things, it appears the two won’t be reconciling anytime soon.

On Friday’s episode of Bravo’s Don’t Be Tardy, Kim let viewers know that her relationship with Karen was over. “My children, I will always be in their life,” the mother of six said. “But my mom? I will not let her back into my life, let’s just be clear.”

It’s not much of a surprise, considering the tense relationship the two women have had in the past. They last spoke at Kim and husband Kroy Biermann’s 2011 wedding, where Karen got into an explosive argument with Kroy when she was denied access to use a private restroom in their home.

Since then, Karen has only made things worse with Kim, 39 — shopping a tell-all book and suing her for grandparent’s visitation of older daughters Brielle, now 20, and Arianna, now 16.

“My mom and I have always butted heads. She’s kind of tormented me for many years,” Kim explained. “Marrying Kroy, you would think it would get easier but it’s actually only gotten worse. It’s one thing messing with Kroy and I, but when you’re messing with my children, it becomes a whole different ballgame for me.”

Karen had recently been making an effort to repair things, though — texting Kim, “Sorry to hear about Kash, call me sometime” after news broke about her son Kash’s terrifying dog bite.

That wasn’t enough for Kim. “My mom knows where I live. You could have sent a card,” she said.

“You can only do so much to a human being,” Kim also told Brielle. “I took it for 34 years until I finally said it’s not worth it to me. My mom, she was good in a lot of aspects. But when my mom told my husband on the day of our wedding to ‘f— off’ and she’s going to burn the f— house down? No”

Still, despite what had happened Brielle wanted to fix things, especially with her grandfather, Joe.

“I still miss him sometimes. He’s still family. He was part of my life for 14 to 15, years,” Brielle said. “They’re going to die one day. Maybe just be cool with each other. Not be friends, I don’t like having grudges and hating these people.”

The idea worked for Kim. “I would never call my mom back in a million years all that she’s done to me and my children. But I’m open to calling Poppy,” she said, using her father’s nickname.

When they called Joe, though, Karen answered the phone instead. And when asked by Brielle if she wanted to get together for dinner the next day, Karen said she couldn’t make it.

“It’s just not gonna work,” Karen said. “We’ve had plans on the calendar for weeks. We can’t just reschedule everything.”

RELATED VIDEO: Kim Zolciak-Biermann Renews Vows to Husband Kroy Biermann in Gorgeous Beach Ceremony

That only upset Kim more. “I just know how I feel about my six kids and I would drop anything to meet them,” she told her mom. “I’ve given birth to children you’ve never met them, and I just don’t get it.”

“I’m floored. I will never understand her mentality. Never,” Kim said, tearing up after hanging up the phone. “I would never do this to . I’m not even sad over them, I just would never do this to . I can’t relate as a mom. I just can’t understand.”

She added, “In time you would think you would change. I would drop anything for my kids. Your family, your blood, is a game to you. That’s what bothers me.”

Don’t Be Tardy airs Fridays (9 p.m. ET) on Bravo .


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Nintendo Will Allow Same-Sex Relationships In New ‘Fire Emblem’ Game

At last, the powerful warriors and wizards in Nintendo’s “Fire Emblem” franchise can be gay.

Gaming site Polygon reported Tuesday that players will be able to have same-sex relationships in the upcoming “Fire Emblem Fates,” a new entry in the strategy role-playing franchise that made its debut on the original Nintendo Entertainment System in 1990. A Nintendo spokesman confirmed this information to The Huffington Post.

“Fates” will be be released in two separate versions, “Conquest” and “Birthright.” Nintendo told HuffPost that each will feature a different same-sex coupling — male in one game and female in the other.

“In the Conquest edition of the game, there is a male character that the game’s player may have his/her male main character marry after they bond in battle. Similarly, the Birthright edition features a female character that a female main character may marry after bonding in battle,” a Nintendo spokesman told HuffPost, echoing the statement given to Polygon.

Having both same-sex relationships in the same game may eventually be possible, since Nintendo says there will be a downloadable component that opens up the content that both versions of the game lack.

For the uninitiated, relationships often play a central role in “Fire Emblem” games. Your characters can make friends and, in the case of the recent “Fire Emblem: Awakening,” hook up with characters of the opposite gender and make beautiful warrior children who travel through time and space to assist you in battle. (There will be procreation in “Fates,” but it’s unclear how this will pertain to the same-sex couples.)

In “Awakening,” you completely customize the main character — named Robin by default — by selecting physical build, facial features, hairstyle, hair color, voice and, of course, gender. Because Nintendo specifically references player-created characters in “Fates,” it seems likely that a similar setup will exist in the new game.


Character creation in “Fire Emblem: Awakening.” (Source)

That lends a bit more weight to the romantic relationships. If you’re playing as a female character, maybe you end up crushing on the blue-haired Chrom — which might feel a bit more personal than having two non-customizable characters get groovy together:


A romantic conversation in “Fire Emblem: Awakening” between a player-created character and a default, Nintendo-made one. (Source)

However, if you’re playing “Awakening” as a female character, you can’t become romantically involved with another female character. Romantic pairings are exclusively heterosexual in releases prior to “Fates.”

There are many other characters running around in the new “Fire Emblem” who could potentially pair off; but it’s unclear if two of the same gender who are built into the story by Nintendo could get together, or if that’s an option only if one of the characters is the one you create for yourself.

In recent years, video games have gotten better about depicting characters who don’t fit a heteronormative mold. The “Mass Effect” series, for example, has allowed characters to pursue fairly in-depth same-sex relationships. Nintendo’s “Fire Emblem” series is generally more kid-friendly than that, which suggests that — when “Fates” hits next year — younger people may have access to a video game that understands them just a bit better than before.

— This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.



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Barbie’s Brand-New Ankles Finally Allow Her to Wear Flats

For as long as we can remember Barbie‘s perpetually been stuck in a tippy-toe stance, ready to slip into heels and…well, stand around. With the unveiling of a brand-new range of dolls, Barbie has finally gotten articulated ankles—joints that actually move, allowing her the option to switch between heels and flats.

new-barbie-has-adjustable-ankles

The big news here isn’t that Barbie’s in flats—it’s that she (via the army of youngsters who play with her) gets to choose what sort of footwear she/they are feeling on any given day. Other dolls feature feet in a perma-flat position (like this and this), but the style pictured above has been crafted with ankle joints so that two pairs of shoes, ankle boots and flats, both work.

Taking Barbie out of a stiletto-only environment certainly registers as a sort of feminist fashion win, but this multi-choice option is actually even bigger. Flats OR pumps? It’s the lady’s right to choose.

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Lights Go on Part XVIII: Allow

How many opportunities have I passed up because I did not allow my self to act upon clear instincts and give attention to what was being presented to me, especially when it felt like a good choice.

It is my belief that instincts come to us in the form of feeling. They are not empirical, they offer no proof. How could they, because instincts deliver possibility.

I believe our instincts are limitless.

Once we actually know something, by proving it through testing, or example or repetition, it becomes knowledge.

It is my belief that knowledge is limited.

Now, I am a fan of knowledge, and it is a prime focus for me to obtain worthwhile knowledge on a daily basis.

Case in point.

I have just finished the first draft of my next book, which is nonfiction and yet closely related to my novel, “Anything Is Possible.” The title of my new book is: “What You Want Wants You” and it explores this immeasurable instinctual knowledge base that is available to all of us.

Through the exercise of writing “Anything Is Possible” Many tenets that I had absorbed from the sage wisdom of my father bubbled up in cogent form. These principles became the basis of “What You Want Wants You”.

This book takes a keen look at and closely deals with a precious phenomenon that every human being possesses. And what is amazing to me is that only we human beings possess it at this high level.

It is called: Free Will.

It was during the writing of AIP that I discovered for myself that Free Will is a great determiner in the success that I have experienced as a human being.

To my mind it is truly the greatest gift of mankind.

Why?

We humans have a choice.

A cognizant choice.

A conscious choice.

We can say yes or no.

I used to think that animals such as lions had a choice, because they would go for the most desirable portion of a kill for themselves. Later on in my development, it became clear to me that a choice of this type was not conscious. It was a reactionary choice, built into them through eons of development at the molecular level.

So we humans possess this thing called ‘Conscious’ choice.

Yay! I think…

Because I find that our subconscious, this wonderland of the unknown that hints and suggests to us on a consistent basis, is easily dominated by our conscious minds.

Our conscious mind knows.

Our unconscious mind suggests.

It is my belief that what our conscious mind knows is only what we have decided, by our own Free Will, to accept as knowledge.
I believe that history will bear me out this. Throughout time immemorial, virtually any level of belief that we once held as truth, was accepted as such because the facts that supported that belief were what we knew and understood consciously at that time.

Yeah, I know, I’m in the deep end of the philosophical pool here.

Don’t blame me! I’m simply following my instincts:)

So, I’d like to dwell for a moment on the opportunity side of possibility that is governed by our Free Will. I began this newsletter by admonishing my self for opportunities passed upon because I consciously ignored my instincts.

Here is an unfortunate tale that supports that statement.

In the mid 90’s I had provided creative services to a start up company that was eventually sold to Microsoft. I had invested in the company shortly before it was sold to Microsoft and ended up riding that incredible money pony that saw my investment multiply by a factor of twenty. It kept on multiplying right into the crash that hit on April 4, 2000, when the Judicial Department declared Microsoft a monopoly.

The stock price was cut in half.

So here are the facts.

I was very busy producing a large show around the time of the crash. Two days before the stock took a huge fall, as I was going over my production schedule I was interrupted by an intruder.

It was my instinct.

And it told me to sell all of my Microsoft stock.

Cash out.

The date was April 2, 2000.

Did I follow this instinct?

This was my bad.

First of all, my Microsoft stock was much too high a percentage of my portfolio. Yet, even my high powered financial friends, one of whom owned his own nationally admired brokerage, suggested that the imbalance in my portfolio was okay because Microsoft was so strong by every measure. If I sold it, what was I going to buy that would even come close to the performance of my Microsoft stock?

So, when my instinct advised me to sell, I did not allow it. I fell back on my conscious knowledge backed by some pretty amazing brain trusts that belied my instinct. Within a day, my net worth was cut in half.

Now, this may be my most extreme example in regard to the consequences of not following that ‘voice’ inside of us that falls prey to our conscious mind. I can also site dozens of instances in which I followed my instincts and was richly rewarded.

A prime example is when I invested in that start up company in the first place. All my pundits, including my wife, thought I was crazy.

I believed in that instinct and acted upon it.

So, what have I learned from all of this?

Call me crazy, but I now listen with great admiration as well as a keen ear to the messages being delivered by my instincts. In fact, I will go so far as to say that I believe that they are messengers of the universe that are truly attempting to reach our consciousness if we grant them permission.

Free Will.

When I allow my instincts to deliver their message and when I act upon those messages, good things happen. It is when I have not allowed my instinctual wisdom to pass by the gatekeeper of my conscious mind that I have suffered most.

I know you have had similar experiences too.

I want to hear your thoughts on this.

2014-05-01-AllowI.jpg
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